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J Hypertens. 2018 Dec;36(12):2434-2443. doi: 10.1097/HJH.0000000000001842.

Blood pressure level associated with lowest cardiovascular event in hypertensive diabetic patients.

Author information

1
Department of Health Promotion, Severance Hospital, Seoul.
2
Department of Computer Science and Statistics, Daegu University, Gyeongbuk.
3
Division of Endocrinology and Metabolism, Department of Internal Medicine.
4
Division of Cardiology, Severance Cardiovascular Hospital and Cardiovascular Research Institute.
5
Department of Preventive Medicine, Yonsei University College of Medicine, Seoul, Republic of Korea.

Abstract

BACKGROUND:

The ACCORD BP trial failed to show the benefit of strict blood pressure (BP) control on cardiovascular events in diabetics with high cardiovascular risk. However, this result cannot be generalized to all diabetics. We investigated whether lower mean BP in diabetic people with hypertension is associated with better prognosis.

METHODS:

Participants from the Korea National Health Insurance Service Health Examinee Cohort who were diagnosed with diabetes and hypertension between 2003 and 2006 were included in the analysis (N = 7926). Mortality and cardiovascular events were compared among three groups according to mean SBP (<130, 130-<140, ≥140 mmHg) and mean DBP (<80, 80-<90, ≥ 90 mmHg) recorded during follow-up health examinations for up to 11 years.

RESULTS:

Significant reductions in the risk of all-cause death, nonfatal myocardial infarction (MI), nonfatal stroke, and end-stage renal disease were observed in patients with a mean SBP of 130 mmHg to less than 140 mmHg, as compared with patients with a mean SBP of at least 140 mmHg. The additional clinical benefit of a mean SBP of less than 130 mmHg was unclear. Lower risk of all-cause death, cardiovascular mortality, and nonfatal strokes was observed in patients with a mean DBP of 80 mmHg to less than 90 mmHg. A mean DBP of less than 80 mmHg was associated with further reduction in all-cause mortality, cardiovascular mortality, ischaemic stroke, and total stroke.

CONCLUSION:

A mean BP of less than 140/80 mmHg was associated with further reduction in the risk of all-cause mortality, cardiovascular mortality, and nonfatal cardiovascular events in diabetic hypertensive patients.

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