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Sichuan Da Xue Xue Bao Yi Xue Ban. 2018 May;49(3):408-413.

[Preliminary Study on Association Between Intestine Microbiota and Blood Glucose,Blood Lipid Metabolism in Middle-aged and Elderly People in Chengdu].

[Article in Chinese]

Author information

1
Department of Nutrition,Food Safety and Toxicology,West China School of Public Health,Sichuan University,Chengdu 610041, China.
2
Huayang Community Health Service Center,Chengdu Tianfu New Area,Chengdu 610213, China.
3
Hebei Inatural Biotech CoLtd,Shijiazhuang 050800,China.

Abstract

OBJECTIVE:

To investigate the possible relationship between the gut microbiota and hyperlipidemia,hyperglycemia in middle-aged and elderly people in Chengdu.

METHODS:

51 of middle-aged and elderly people participated in this study. The concentration of blood glucose and lipid,and the other physiological parameters of the subjects were analyzed,and their fecal microbiota was also profiled by Illumina high-throughput sequencing technique.

RESULTS:

The fecal microbiota in the middle-aged and elderly were mainly Firmicutes,Bacteroidetes,Proteobacteria,Fusobacteria,Actinobacteria,Verrucomicrobia. The diversity offecalmicrobiota was significantly lower in the subjects with higher blood glucose (P<0.05),while it did not exhibited relationship with changes in blood lipids. At the bacterial phyla: Proteobacteria and Bacteroidetes were respectively significantly higher in middle-aged and elderly women with higher blood glucose (P<0.05). At the bacterial genus: Faecalibacterium was significantly lower in the hyperglycemic subjects (P<0.05),its abundance and blood glucose levels were negatively correlated (r=⁻0.278,P=0.048); Prevotella and Paraprevotella were significantly lower in the high blood lipids group (P<0.05),and both of them were negatively correlated with blood lipid levels (r=⁻0.357,P=0.10; r=⁻0.365,P=0.008).

CONCLUSION:

The fecal microbiota in the tested middle-aged and elderly subjects varied with blood glucose and blood lipid concentration. Intestinal microbes might posses close relationship with blood glucose and lipid metabolism in middle-aged and elderly people.

KEYWORDS:

Blood glucose ; Blood lipid ; Gutmi crobiota ; High-throughput sequencing technology

PMID:
30014644
[Indexed for MEDLINE]

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