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Nat Commun. 2018 Jul 16;9(1):2735. doi: 10.1038/s41467-018-05131-6.

Hippocampal projections to the anterior olfactory nucleus differentially convey spatiotemporal information during episodic odour memory.

Author information

1
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada, M5S 3G5.
2
Department of Cell and Systems Biology, University of Toronto, Toronto, Ontario, Canada, M5S 3G5. kim@psych.utoronto.ca.
3
Department of Psychology, University of Toronto, Toronto, Ontario, Canada, M5S 3G3. kim@psych.utoronto.ca.

Abstract

The hippocampus is essential for representing spatiotemporal context and establishing its association with the sensory details of daily life to form episodic memories. The olfactory cortex in particular shares exclusive anatomical connections with the hippocampus as a result of their common evolutionary history. Here we selectively inhibit hippocampal projections to the anterior olfactory nucleus (AON) during behavioural tests of contextually cued odour recall. We find that spatial odour memory and temporal odour memory are independently impaired following inhibition of distinct, topographically organized hippocampal-AON pathways. Our results not only reveal a longstanding unknown function for the AON but offer new mechanistic insights regarding the representation of odours in episodic memory.

PMID:
30013078
PMCID:
PMC6048034
DOI:
10.1038/s41467-018-05131-6
[Indexed for MEDLINE]
Free PMC Article

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