Format

Send to

Choose Destination
Clin Rehabil. 2019 Jan;33(1):113-119. doi: 10.1177/0269215518787324. Epub 2018 Jul 17.

Screening for cognitive deficits with the Evaluation of Cognitive Processes involved in Disability in Schizophrenia scale.

Author information

1
1 Fondation FondaMental, Créteil, France.
2
2 Department of Adult Psychiatry, Versailles Hospital, Le Chesnay, France.
3
3 HandiRESP Laboratory, EA4047, Health Sciences Department Simone Veil, University of Versailles Saint-Quentin-En-Yvelines, Montigny-le-Bretonneux, France.
4
4 Strasbourg University Hospital, INSERM U1114, Strasbourg Federation of Translational Psychiatry, University of Strasbourg, Strasbourg, France.
5
5 INSERM U955, Translational Psychiatry Team, Université Paris-Est Créteil (UPEC), AP-HP, DHU Pe-PSY, Department of Adult Psychiatry, Henri Mondor University Hospitals, Créteil, France.
6
6 University Department of Adult Psychiatry, La Colombière Hospital, CHU Montpellier, University of Montpellier 1, INSERM 1061, Montpellier, France.
7
7 CMP B, Clermont-Ferrand University Hospital, EA 7280, Faculty of Medicine, Auvergne University, Clermont-Ferrand Cedex 1, France.
8
8 Psychosocial Rehabilitation Reference Centre, Alpes Isère Hospital, Grenoble, France.
9
9 Academic Department of Psychiatry (AP-HM), Sainte-Marguerite University Hospital, Marseille, France.

Abstract

OBJECTIVE::

This study aimed to evaluate the validity of the Evaluation of Cognitive Processes involved in Disability in Schizophrenia scale (ECPDS) to discriminate for cognitive impairment in schizophrenia.

DESIGN::

This multicentre cross-sectional study used a validation design with receiver operating characteristic (ROC) curve analysis.

SETTINGS::

The study was undertaken in a French network of seven outward referral centres.

SUBJECTS::

We recruited individuals with clinically stable schizophrenia diagnosed based on the Structured Clinical Interview for assessing Diagnostic and Statistical Manual of Mental Disorders (4th ed., rev.; DSM-IV-R) criteria.

MAIN MEASURES::

The index test for cognitive impairment was ECPDS (independent variable), a 13-item scale completed by a relative of the participant. The reference standard was a standardized test battery that evaluated seven cognitive domains. Cognitive impairment was the dependent variable and was defined as an average z-score more than 1 SD below the normative mean in two or more cognitive domains.

RESULTS::

Overall, 97 patients were included (67 with schizophrenia, 28 with schizoaffective disorder, and 2 with schizophreniform disorder). The mean age was 30.2 (SD 7.7) years, and there were 75 men (77.3%). There were 59 (60.8%) patients with cognitive impairment on the neuropsychological battery, and the mean ECPDS score was 27.3 (SD 7.3). The ROC curve analysis showed that the optimal ECPDS cut-off was 29.5. The area under the curve was 0.77, with 76.3% specificity and 71.1% sensitivity to discriminate against cognitive impairment.

CONCLUSION::

The ECPDS is a valid triage tool for detecting cognitive impairment in schizophrenia, before using an extensive neuropsychological battery, and holds promise for use in everyday clinical practice.

KEYWORDS:

Chronic disability; cognitive impairment; psychiatric rehabilitation; schizophrenia; sensitivity; specificity

PMID:
30012064
DOI:
10.1177/0269215518787324
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Atypon
Loading ...
Support Center