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PLoS Genet. 2018 Jul 16;14(7):e1007519. doi: 10.1371/journal.pgen.1007519. eCollection 2018 Jul.

The lncRNA male-specific abdominal plays a critical role in Drosophila accessory gland development and male fertility.

Author information

1
Department of Genetics and Evolution, University of Geneva, Geneva, Switzerland.
2
Department of Molecular Biology and Genetics, Cornell University, Ithaca, New York, United States of America.

Abstract

Although thousands of long non-coding RNAs (lncRNA) have been identified in the genomes of higher eukaryotes, the precise function of most of them is still unclear. Here, we show that a >65 kb, male-specific, lncRNA, called male-specific abdominal (msa) is required for the development of the secondary cells of the Drosophila male accessory gland (AG). msa is transcribed from within the Drosophila bithorax complex and shares much of its sequence with another lncRNA, the iab-8 lncRNA, which is involved in the development of the central nervous system (CNS). Both lncRNAs perform much of their functions via a shared miRNA embedded within their sequences. Loss of msa, or of the miRNA it contains, causes defects in secondary cell morphology and reduces male fertility. Although both lncRNAs express the same miRNA, the phenotype in the secondary cells and the CNS seem to reflect misregulation of different targets in the two tissues.

PMID:
30011265
PMCID:
PMC6067764
DOI:
10.1371/journal.pgen.1007519
[Indexed for MEDLINE]
Free PMC Article

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