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Cereb Cortex. 2018 Jul 12. doi: 10.1093/cercor/bhy165. [Epub ahead of print]

Synaptic Mechanisms for Bandwidth Tuning in Awake Mouse Primary Auditory Cortex.

Li H1,2, Liang F2,3, Zhong W1,2, Yan L1,2, Mesik L2,4, Xiao Z1, Tao HW2,5, Zhang LI2,5.

Author information

1
Department of Physiology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China.
2
Zilkha Neurogenetic Institute, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.
3
Department of Medical Engineering, School of Biomedical Engineering, Southern Medical University, Guangzhou, China.
4
Neuroscience Graduate Program, University of Southern California, Los Angeles, CA, USA.
5
Department of Physiology and Neuroscience, Keck School of Medicine, University of Southern California, Los Angeles, CA, USA.

Abstract

Spatial size tuning in the visual cortex has been considered as an important neuronal functional property for sensory perception. However, an analogous mechanism in the auditory system has remained controversial. In the present study, cell-attached recordings in the primary auditory cortex (A1) of awake mice revealed that excitatory neurons can be categorized into three types according to their bandwidth tuning profiles in response to band-passed noise (BPN) stimuli: nonmonotonic (NM), flat, and monotonic, with the latter two considered as non-tuned for bandwidth. The prevalence of bandwidth-tuned (i.e., NM) neurons increases significantly from layer 4 to layer 2/3. With sequential cell-attached and whole-cell voltage-clamp recordings from the same neurons, we found that the bandwidth preference of excitatory neurons is largely determined by the excitatory synaptic input they receive, and that the bandwidth selectivity is further enhanced by flatly tuned inhibition observed in all cells. The latter can be attributed at least partially to the flat tuning of parvalbumin inhibitory neurons. The tuning of auditory cortical neurons for bandwidth of BPN may contribute to the processing of complex sounds.

PMID:
30010857
DOI:
10.1093/cercor/bhy165

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