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Ann Clin Transl Neurol. 2018 May 21;5(7):788-802. doi: 10.1002/acn3.574. eCollection 2018 Jul.

Altered dynamics of neurovascular coupling in CADASIL.

Author information

1
Laboratoire des Sciences du Numérique de Nantes - LS2N Centre National de la Recherche Scientifique UMR6004 Université de Nantes Nantes France.
2
Laboratoire d'Imagerie Biomédicale Centre de la Recherche Scientifique UMR7371 Inserm UMR1146 Université Pierre et Marie Curie Paris VI Paris France.
3
Centre of Excellence of Neurodegenerative Disease - CoEN ICM, APHP Department of Neurology Hôpital Pitié-Salpêtrière Institute of Memory and Alzheimer's Disease - IM2A University Paris 6 Paris France.
4
Sorbonne Paris Cité Inserm UMR1161 Université Denis Diderot Paris VII Paris France.
5
Centre de Neuro-Imagerie de Recherche - CENIR Institut du Cerveau et de la Moelle épinière - ICM Paris France.
6
Département de Neurologie and DHU NeuroVasc AP-HP Hôpital Lariboisière Paris France.
7
Faculty of Engineering and Computer Science University Concordia Quebec Canada.

Abstract

Background and Objective:

Neurovascular coupling is the complex biological process that underlies use-dependent increases in blood flow in response to neural activation. Neurovascular coupling was investigated at the early stage of CADASIL, a genetic paradigm of ischemic small vessel disease.

Methods:

Functional hyperemia and evoked potentials during 20- and 40-sec visual and motor stimulations were monitored simultaneously using arterial spin labeling-functional magnetic resonance imaging (ASL-fMRI) and electroencephalography.

Results:

Cortical functional hyperemia differed significantly between 19 patients and 19 healthy individuals, whereas evoked potentials were unaltered. Functional hyperemia dynamics, assessed using the difference in the slope of the response curve between 15 and 30 sec, showed a time-shifted decrease in the response to 40-sec neural stimulations in CADASIL patients. These results were replicated in a second cohort of 10 patients and 10 controls and confirmed in the whole population.

Interpretation:

Alterations of neurovascular coupling occur early in CADASIL and can be assessed by ASL-fMRI using a simple marker of vascular dysfunction.

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