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Carbohydr Polym. 2018 Oct 1;197:598-607. doi: 10.1016/j.carbpol.2018.06.038. Epub 2018 Jun 8.

Neuroprotective properties of Cantharellus cibarius polysaccharide fractions in different in vitro models of neurodegeneration.

Author information

1
Department of Medical Biology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-090 Lublin, Poland. Electronic address: lemieszek.marta@imw.lublin.pl.
2
CQ-Vila Real, Food and Wine Chemistry Lab., Chemistry Research Centre, Chemistry Department, University of Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal.
3
Department of Agronomy, University of Trás-os-Montes e Alto Douro, 5001-801 Vila Real, Portugal.
4
Department of Medical Biology, Institute of Agricultural Medicine, Jaczewskiego 2, 20-090 Lublin, Poland; Department of Virology and Immunology, Maria Curie-Skłodowska University, Akademicka 19, 20-033 Lublin, Poland.

Abstract

The percentage of people suffering from neurodegenerative diseases is constantly increasing, because of that searching for substances able to prevent or inhibit neuronal death sseems to be reasonable. Because of the high popularity the search of new neuroprotective agents we started from Cantharellus cibarius. Neuroprotective properties of C. cibarius polysaccharides fractions was investigated in different models of neurodegeneration including trophic stress, excitotoxicity and andoxidative stress. Fractions influence on neurons viability was examined using Neurite Outgrowth Staining, MTT and LDH tests, while antioxidant capacity was determined by commercial antioxidant assays. Performed studies revealed beneficial effect of C. cibarius fractions (CC2a, CC3) on neurons viability and neurite outgrowth in normal and different stress conditions. Both tested fractions have shown antioxidant capacity and effectively neutralize the negative changes induced by glutamatergic system activators. Discovered neuroprotective properties of investigated compounds suggested the their use for developing effective and safety therapeutic strategy for neurodegenerative diseases.

KEYWORDS:

Antioxidant; Cantharellus cibarius; Excitotoxicity; Golden chanterelle; Neurons; Trophic stress

PMID:
30007652
DOI:
10.1016/j.carbpol.2018.06.038
[Indexed for MEDLINE]

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