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Sci Rep. 2018 Jul 13;8(1):10653. doi: 10.1038/s41598-018-28879-9.

Multidrug-resistant Citrobacter freundii ST139 co-producing NDM-1 and CMY-152 from China.

Author information

1
Academy of Military Medical Sciences, Beijing, China.
2
Institute for Disease Control and Prevention of PLA, Beijing, China.
3
Institute for Disease Control and Prevention of PLA, Beijing, China. jiekenlee@126.com.
4
Institute for Disease Control and Prevention of PLA, Beijing, China. qiushf0613@hotmail.com.

Abstract

The emergence of carbapenemase-producing Citrobacter freundii poses a significant threat to public health worldwide. Here, we reported a C. freundii strain CWH001 which was resistant to all tested antimicrobials except tetracycline. Whole genome sequencing and analysis were performed. The strain, which belonged to a new sequence type ST139, showed close relationship with other foreign C. freundii strains through phylogenetic analysis. A novel variant of the intrinsic blaCMY gene located on the chromosome was identified and designated as blaCMY-152. Coexistence of blaNDM-1 with qnrS1 was found on a conjugative IncN plasmid, which had a backbone appearing in various plasmids. Other class A ESBL genes (blaVEB-3 and blaTEM-1) were also detected on two different novel plasmids. The emergence of multidrug-resistant C. freundii is of major concern, causing great challenges to the treatment of clinical infections. Great efforts need to be taken for the specific surveillance of this opportunistic pathogen.

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