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Schizophr Res. 2018 Dec;202:180-187. doi: 10.1016/j.schres.2018.07.009. Epub 2018 Jul 10.

Role of frontal white matter and corpus callosum on social function in schizophrenia.

Author information

1
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan.
2
Division of Cerebral Integration, National Institute for Physiological Sciences, Aichi, Japan.
3
Department of Neuropsychiatry, Graduate School of Medicine, The University of Tokyo, Tokyo, Japan; International Research Center for Neurointelligence (WPI-IRCN), UTIAS, The University of Tokyo, Tokyo, Japan.
4
Department of Psychiatry, Faculty of Medicine, University of Tsukuba, Ibaraki, Japan.
5
Division of Ultrahigh Field MRI, Institute for Biomedical Sciences, Iwate Medical University, Iwate, Japan.
6
Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan.
7
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States of America; Harvard Medical School, Boston, MA, United States of America.
8
Imaging Genetics Center, Mark and Mary Stevens Neuroimaging and Informatics Institute, Keck School of Medicine, University of Southern California, Marina del Rey, CA, United States of America.
9
Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan.
10
Diagnostic and Interventional Radiology, Osaka University Graduate School of Medicine, Osaka, Japan.
11
Centre for Neuroimaging & Cognitive Genomics (NICOG), Clinical Neuroimaging Laboratory, NCBES Galway Neuroscience Centre, College of Medicine Nursing and Health Sciences, National University of Ireland Galway, Galway, Ireland.
12
Department of Psychiatry, Osaka University Graduate School of Medicine, Osaka, Japan; Molecular Research Center for Children's Mental Development, United Graduate School of Child Development, Osaka University, Osaka, Japan. Electronic address: hashimor@psy.med.osaka-u.ac.jp.

Abstract

Patients with schizophrenia show severe impairment in social function and have difficulty in their daily social life. Although a recent large-scale multicenter study revealed alterations in white matter microstructures, the association between these anatomical changes and social dysfunction in schizophrenia remains unknown. Therefore, we investigated the association between the white matter integrity of regions of interest and social function in schizophrenia. A total of 149 patients with schizophrenia and 602 healthy comparison subjects (HCS) underwent DTI and completed the Picture Arrangement subtest of the Wechsler Adult Intelligence Scale-Third Edition and the Finance subscale of the University of California, San Diego, Performance-Based Skills Assessment Brief, as social indices of interest. The fractional anisotropy (FA) in the anterior corona radiata and corpus callosum was significantly lower in patients than in HCS, and the radial diffusivity (RD) in the anterior corona radiata and corpus callosum was significantly higher in patients. The Picture Arrangement and Finance scores were both significantly impaired in patients. The effect of the FA of the right anterior corona radiata on the Finance score and the Picture Arrangement score, of the RD of the right anterior corona radiata on the Picture Arrangement score, and of the RD of the corpus callosum on the Picture Arrangement score were significant. In conclusion, our results confirmed the association between structural connectivity in the right frontal white matter and corpus callosum and social function in schizophrenia. These findings may provide a foundation for developing an intervention for functional recovery in schizophrenia.

KEYWORDS:

Anterior corona radiata; Diffusion tensor imaging (DTI); Fractional anisotropy (FA); Radial diffusivity (RD); University of California, San Diego, Performance-Based Skills Assessment Brief (UPSA-B); Wechsler Adult Intelligence Scale-Third Edition (WAIS-III)

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