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Acta Clin Belg. 2019 Aug;74(4):252-257. doi: 10.1080/17843286.2018.1495389. Epub 2018 Jul 13.

Bone mineral density and serum osteocalcin levels in patients with gout.

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a Department of Internal Medicine, Division of Rheumatology , Dr. Ersin Arslan Training and Research Hospital , Gaziantep , Turkey.
b Department of Internal Medicine, Division of Rheumatology , Antalya Training and Research Hospital , Antalya , Turkey.
c Department of Internal Medicine , Pamukkale University , Denizli , Turkey.
d Department of Internal Medicine, Division of Rheumatology , Pamukkale University , Denizli , Turkey.
e Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology , Suleyman Demirel University , Isparta , Turkey.


Objective: The objective of the study is to evaluate the relation of gout with osteoporosis and serum osteocalcin (OC) levels. Material and methods: Seventy-five patients diagnosed with gout and 55 controls were included in the study. Comorbid conditions and drugs associated with osteoporosis were excluded. The T and Z scores from lumbar spine (L2-L4) and femur (neck, ward, trochanter, total) were determined by dual-energy X-ray absorptiometry (DXA). OC levels were measured by enzyme-linked immunosorbent assay. Results: Osteoporosis according to T scores of lumbar vertebrae L2-L4 was found to be significantly higher in patients with gout compared to the control group (p = 0.02). Lumbar spine T-score was -1.6 in gout group and -1.0 in controls. OC level was 7.9 ng/mL in the gout group and 18.9 ng/mL in the control group. There was a significant difference (< 0.001). In addition, mean OC level was 12.4 ± 6.9 ng/mL in the patients diagnosed with osteoporosis and 17.2 ± 10.6 ng/mL in the patients that were classified as normal and a significant difference was established between the two groups (= 0.03). A significant negative correlation was found between OC level and body mass index, age, and age at first attack. Similarly, femoral T-score established a negative correlation with parathyroid hormone, age, age at first attack, and allopurinol dose. Conclusion: Serum OC level can be a useful marker in the assessment of bone turnover and clinicians should keep osteoporosis in mind in gout patients.


Gout; Osteocalcin; Osteoporosis

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