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Haemophilia. 2018 Sep;24(5):747-754. doi: 10.1111/hae.13585. Epub 2018 Jul 13.

Risk factors for cardiovascular disease in children and young adults with haemophilia.

Author information

1
Rady Children's Hospital San Diego, San Diego, California.
2
Rady Children's Hospital San Diego, UC San Diego, La Jolla, California.

Abstract

INTRODUCTION:

The origins of cardiovascular disease (CVD) begin in childhood. The primary objective of this cross-sectional cohort study was to determine the prevalence of cardiovascular risk factors in patients with congenital haemophilia A or B followed at Rady Children's Hospital San Diego Hemophilia and Thrombosis Treatment Center (HTC). We hypothesized that cardiovascular risk factors could be identified as part of a comprehensive clinic visit.

MATERIALS AND METHODS:

Standardized measurement of weight, height, waist circumference and blood pressure plus non-fasting glucose and lipid panel were performed. Participants and/or caregivers completed questionnaires about family history, medical history and lifestyle. Clinical data were abstracted from the medical record. Descriptive statistics, Student's t test, correlation, Mann-Whitney U test and chi-square test were performed to analyse the data.

RESULTS:

Forty-three males (mean 12 years, range 5-20 years) enrolled. High rates of overweight and obesity, (pre)hypertension and abnormal lipids were identified. Subjects with normal weight had more days of >60 minutes of physical activity compared with those with overweight or obesity (5.2 ± 2.4 vs. 3.8 ± 2.5 day; P = 0.07). Higher weight was correlated with higher factor consumption (cor = 0.88; P < 0.001). There was no difference in target joints based on weight category (30% in normal weight vs. 25% in overweight or obese, χ2 = 0.11, P = 0.74), which may be attributed to high rates of prophylaxis.

CONCLUSIONS:

Modifiable risk factors for CVD were identified as part of the study during comprehensive clinic visits. The HTC team may develop behavioural interventions to target cardiovascular risk reduction as part of the comprehensive care model.

KEYWORDS:

cardiovascular disease; haemophilia; hypertension; obesity; overweight

PMID:
30004151
PMCID:
PMC6153073
DOI:
10.1111/hae.13585
[Indexed for MEDLINE]
Free PMC Article

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