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Biochem Biophys Res Commun. 1985 Nov 27;133(1):37-43.

Neurotoxic insecticides inhibit GABA-dependent chloride uptake by mouse brain vesicles.

Abstract

The neurotoxic insecticides endrin, dieldrin, aldrin, lindane (gamma-1,2,3,4,5,6-hexachlorocyclohexane) and deltamethrin inhibited gamma-aminobutyric acid-dependent 36Cl- uptake by mouse brain vesicles. Of the insecticides examined, the chlorinated cyclodienes endrin and dieldrin were the most potent, producing 50% inhibition at 2.8 and 13.9 microM, respectively. Lindane and deltamethrin were less effective, and with deltamethrin the effect was incompletely stereospecific. These results demonstrate the disruption of gamma-aminobutyric acid receptor-chloride ionophore function in mammalian brain by neurotoxic insecticides and provide evidence that this complex is the principal site of cyclodiene action.

PMID:
3000377
DOI:
10.1016/0006-291x(85)91838-8
[Indexed for MEDLINE]

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