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Heart Lung. 2018 Sep - Oct;47(5):489-496. doi: 10.1016/j.hrtlng.2018.05.015. Epub 2018 Jul 9.

Effects of music intervention on inflammatory markers in critically ill and post-operative patients: A systematic review of the literature.

Author information

1
Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN. Electronic address: sikhan@iu.edu.
2
Department of Medicine, Indiana University School of Medicine, Indianapolis, IN.
3
Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN.
4
Department of Psychiatry, Indiana University School of Medicine, Indianapolis, IN.
5
Department of Nursing, Nursing Research Division, Mayo Clinic, Rochester, MN.
6
Indiana University Center of Health Innovation and Implementation Science, Indianapolis, IN; IU Center of Aging Research, Regenstrief Institute, Indianapolis, IN; Sandra Eskenazi Center for Brain Care Innovation, Eskenazi Hospital, Indianapolis, IN; Division of Geriatrics and General Internal Medicine, Department of Internal Medicine, Indiana University School of Medicine, Indianapolis, IN; Indiana Clinical and Translational Research Institute, Indiana University School of Medicine, Indianapolis, Indiana.
7
Division of Pulmonary, Critical Care, Sleep and Occupational Medicine, Indiana University School of Medicine, Indianapolis, IN; Indiana University Center of Health Innovation and Implementation Science, Indianapolis, IN; Indiana Clinical and Translational Research Institute, Indiana University School of Medicine, Indianapolis, Indiana.

Abstract

BACKGROUND:

Music listening has been shown to reduce anxiety, stress, and patient tolerance of procedures. Music may also have beneficial effects on inflammatory biomarkers in intensive care and post-operative patients, but the quality of evidence is not clear.

OBJECTIVES:

We conducted a systematic review to evaluate the effects of music on inflammatory biomarkers in intensive care, and post-operative patients.

METHODS:

A comprehensive search of the literature was performed. After screening 1570 references, full text review of 26 studies was performed. Fourteen studies were selected for inclusion.

RESULTS:

Seven studies showed a significant decrease in cortisol levels, but the level of evidence was low. Three studies had low risk of methodological bias, while 11 studies had high risk of bias.

CONCLUSIONS:

Music intervention may decrease cortisol levels, but other biomarkers remain unchanged. Given the low level of evidence, further research on music effects on inflammatory biomarkers is needed.

KEYWORDS:

Biomarkers; Brain dysfunction; Cortisol; Delirium; Music; Stress

PMID:
30001799
PMCID:
PMC6380515
DOI:
10.1016/j.hrtlng.2018.05.015
[Indexed for MEDLINE]
Free PMC Article

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