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Cell Host Microbe. 2018 Jul 11;24(1):43-56. doi: 10.1016/j.chom.2018.06.008.

Malaria Vaccines: Recent Advances and New Horizons.

Author information

1
The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK. Electronic address: simon.draper@ndm.ox.ac.uk.
2
Center for Infectious Disease Research, 307 Westlake Ave N., Seattle, WA 98109, USA.
3
PATH's Malaria Vaccine Initiative (MVI), 455 Massachusetts Avenue NW, Suite 1000, Washington, DC 20001-2621, USA.
4
The Jenner Institute, University of Oxford, Old Road Campus Research Building, Oxford, OX3 7DQ, UK.
5
Malaria Programme, Wellcome Sanger Institute, Cambridge, CB10 1SA, UK.
6
Department of Biochemistry, University of Oxford, South Parks Road, Oxford, OX1 3QU, UK.
7
Laboratory of Malaria and Vector Research, NIAID/NIH, Rockville, MD 20852, USA.
8
Vaccine Research Center, NIAID/NIH, Bethesda, MD 20892, USA.

Abstract

The development of highly effective and durable vaccines against the human malaria parasites Plasmodium falciparum and P. vivax remains a key priority. Decades of endeavor have taught that achieving this goal will be challenging; however, recent innovation in malaria vaccine research and a diverse pipeline of novel vaccine candidates for clinical assessment provides optimism. With first-generation pre-erythrocytic vaccines aiming for licensure in the coming years, it is important to reflect on how next-generation approaches can improve on their success. Here we review the latest vaccine approaches that seek to prevent malaria infection, disease, and transmission and highlight some of the major underlying immunological and molecular mechanisms of protection. The synthesis of rational antigen selection, immunogen design, and immunization strategies to induce quantitatively and qualitatively improved immune effector mechanisms offers promise for achieving sustained high-level protection.

PMID:
30001524
PMCID:
PMC6054918
DOI:
10.1016/j.chom.2018.06.008
[Indexed for MEDLINE]
Free PMC Article

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