Maternal doses of olanzapine up to 20 mg daily produce low levels in milk and undetectable levels in the serum of breastfed infants. In most cases, short-term side effects have not been reported, but sedation has occurred. Limited long-term follow-up of infants exposed to olanzapine indicates that infants generally developed normally. A safety scoring system finds olanzapine to be acceptable during breastfeeding.[1] Systematic reviews of second-generation antipsychotics concluded that olanzapine seems to be a first-line agent during breastfeeding.[2-4]Monitor the infant for drowsiness and developmental milestones, especially if other antipsychotics are used concurrently.