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Front Med (Lausanne). 2018 Jun 26;5:188. doi: 10.3389/fmed.2018.00188. eCollection 2018.

Oral Photoprotection: Effective Agents and Potential Candidates.

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Department of Histology and Pathology, University of Málaga, Málaga, Spain.
School of Natural Sciences, Fairleigh Dickinson University, Teaneck, NJ, United States.
Dermatology Service, Hospital Miguel Servet, Zaragoza, Spain.
Dermatology, Hospital Universitario Miguel Servet, Zaragoza, Spain.
Biology Department, Instituto Ramón y Cajal de Investigación Sanitaria, Universidad Autónoma de Madrid, Madrid, Spain.
Medicine and Medical Specialties Department, Instituto Ramón y Cajal de Investigación Sanitaria, Alcalá University Madrid, Madrid, Spain.


Electromagnetic radiation in the ultraviolet, visible, and infrared ranges produces biologic effects in humans. Where some of these effects are beneficial, others are harmful to the skin, particularly those stemming from ultraviolet radiation (UVR). Pharmacological photoprotection can be topical or systemic. Systemic photoprotection is often administered orally, complementing topical protection. New and classic oral agents (e.g., essential micronutrients as vitamins, minerals, polyphenols, carotenoids) are endowed with photoprotective and anti-photocarcinogenic properties. These substances bear the potential to increase systemic protection against the effects of electromagnetic radiation in the UV, visible, and infrared ranges. Protective mechanisms vary and include anti-oxidant, anti-inflammatory, and immunomodulatory effects. As such, they provide protection against UVR and prevent photo-induced carcinogenesis and aging. In this review, we present state of the art approaches regarding the photoprotective effects of vitamins and vitamin derivatives, dietary botanical, and non-botanical agents. A growing body of data supports the beneficial effects of oral photoprotection on the health of the skin. More studies will likely confirm and expand the positive impact of oral dietary botanicals as complementary measures for photoprotection.


dietary botanical; oral photoprotection; oxidative stress; photocarcinogenesis; photodamage

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