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Sci Total Environ. 2018 Jun 1;625:940-962. doi: 10.1016/j.scitotenv.2017.12.334. Epub 2018 Jan 12.

Review of in vitro toxicological research of quantum dot and potentially involved mechanisms.

Author information

1
Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing, Jiangsu, 210009, China; Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, Jiangsu, 210009, China.
2
Key Laboratory of Environmental Medicine Engineering of Ministry of Education, School of Public Health & Collaborative Innovation Center of Suzhou Nano Science and Technology, Southeast University, Nanjing, Jiangsu, 210009, China; Jiangsu Key Laboratory for Biomaterials and Devices, Southeast University, Nanjing, Jiangsu, 210009, China. Electronic address: tm@seu.edu.cn.

Abstract

Quantum dots (QDs) are one of emerging engineering nanomaterials (NMs) with advantageous properties which can act as candidates for clinical imaging and diagnosis. Nevertheless, toxicological studies have proved that QDs for better or worse pose threats to diverse systems which are attributed to the release of metal ion and specific characteristics of nanoparticles (NPs), hampering the wide use of QDs to biomedical area. It has been postulated that mechanisms of toxicity evoked by QDs have implications in oxidative stress, reactive oxygen species (ROS), inflammation and release of metal ion. Meanwhile, DNA damage and disturbance of subcellular structures would occur during QDs treatment. This review is intended to conclude the cytotoxicity of QDs in multiple systems, as well as the potential mechanisms on the basis of recent literatures. Finally, toxicity-related factors are clarified, among which chirality seems to be a newly proposed influence factor that determines the destiny of cells in response to QDs. However, details of interaction between QDs and cells have not been well elucidated. Given that molecular mechanisms of QDs-induced toxicity are still not clearly elucidated, further research should be required for this meaningful topic.

KEYWORDS:

Chirality; Cytotoxicity; Endoplasmic reticulum (ER) stress; Inflammation; Quantum dot (QD); ROS

PMID:
29996464
DOI:
10.1016/j.scitotenv.2017.12.334
[Indexed for MEDLINE]

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