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Medicine (Baltimore). 2018 Jul;97(28):e11379. doi: 10.1097/MD.0000000000011379.

Male pattern baldness and incidence of prostate cancer: A systematic review and meta-analysis.

He H1,2, Xie B3, Xie L1.

Author information

1
Department of Urology, First Affiliated Hospital, School of Medicine, Zhejiang University.
2
Department of Urology, Affiliated Hangzhou First People's Hospital, Zhejiang University School of Medicine.
3
Department of Urology, Tongde Hospital of Zhejiang Province, Hangzhou, Zhejiang, China.

Abstract

BACKGROUND:

The relationship between male pattern baldness and incidence of prostate cancer remains inconclusive. Hence, we performed the present meta-analysis based on all eligible cohort and case-control studies.

METHODS:

A comprehensive literature search was performed in October 2017 based on PubMed and Web of Science databases. Pooled relative risk (RR) and its 95% confidence interval (95% CI) was calculated with a DerSimonian and Laird random-effects model.

RESULTS:

A total of 15 studies were included in this meta-analysis. Overall, no statistically significant association between baldness (any pattern) and prostate cancer risk was identified (RR: 1.03, 95% CI 0.96-1.11). There was obvious heterogeneity across included studies (P < .078 for heterogeneity, I = 36.4%). When subgroup analysis by types of baldness, a statistically significant association was observed for vertex baldness (RR 1.24, 95% CI 1.05-1.46) but not for other types of baldness.

CONCLUSION:

Individuals with vertex baldness may have an increased risk of prostate cancer. Given the obvious heterogeneity and null results in overall analysis and most of subgroup analyses, further large well-designed prospective cohort studies are warranted to confirm our preliminary findings.

PMID:
29995779
PMCID:
PMC6076190
DOI:
10.1097/MD.0000000000011379
[Indexed for MEDLINE]
Free PMC Article

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