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Neurosci Bull. 2018 Aug;34(4):659-667. doi: 10.1007/s12264-018-0252-4. Epub 2018 Jul 11.

Spinal Cord Stimulation Frequency Influences the Hemodynamic Response in Patients with Disorders of Consciousness.

Si J1, Dang Y2, Zhang Y3,4, Li Y1, Zhang W1, Yang Y2, Cui Y3,4, Lou X1, He J5, Jiang T6,7,8,9,10.

Author information

1
School of Instrumentation Science and Opto-electronics Engineering, Beijing Information Science and Technology University, Beijing, 100192, China.
2
Department of Neurosurgery, People's Liberation Army General Hospital, Beijing, 100700, China.
3
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
4
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China.
5
Department of Neurosurgery, People's Liberation Army General Hospital, Beijing, 100700, China. he_jianghong@sina.cn.
6
Brainnetome Center, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. jiangtz@nlpr.ia.ac.cn.
7
National Laboratory of Pattern Recognition, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. jiangtz@nlpr.ia.ac.cn.
8
Key Laboratory for NeuroInformation of the Ministry of Education, School of Life Science and Technology, University of Electronic Science and Technology of China, Chengdu, 625014, China. jiangtz@nlpr.ia.ac.cn.
9
Chinese Academy of Sciences Center for Excellence in Brain Science, Institute of Automation, Chinese Academy of Sciences, Beijing, 100190, China. jiangtz@nlpr.ia.ac.cn.
10
Queensland Brain Institute, University of Queensland, St. Lucia, QL, 4072, Australia. jiangtz@nlpr.ia.ac.cn.

Abstract

Spinal cord stimulation (SCS) is a promising technique for treating disorders of consciousness (DOCs). However, differences in the spatio-temporal responsiveness of the brain under varied SCS parameters remain unclear. In this pilot study, functional near-infrared spectroscopy was used to measure the hemodynamic responses of 10 DOC patients to different SCS frequencies (5 Hz, 10 Hz, 50 Hz, 70 Hz, and 100 Hz). In the prefrontal cortex, a key area in consciousness circuits, we found significantly increased hemodynamic responses at 70 Hz and 100 Hz, and significantly different hemodynamic responses between 50 Hz and 70 Hz/100 Hz. In addition, the functional connectivity between prefrontal and occipital areas was significantly improved with SCS at 70 Hz. These results demonstrated that SCS modulates the hemodynamic responses and long-range connectivity in a frequency-specific manner (with 70 Hz apparently better), perhaps by improving the cerebral blood volume and information transmission through the reticular formation-thalamus-cortex pathway.

KEYWORDS:

Disorder of consciousness; Frequency; Functional near-infrared spectroscopy; Hemodynamic response; Spinal cord stimulation

PMID:
29995275
PMCID:
PMC6060214
DOI:
10.1007/s12264-018-0252-4
[Indexed for MEDLINE]
Free PMC Article

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