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Nat Commun. 2018 Jul 11;9(1):2679. doi: 10.1038/s41467-018-04990-3.

Systemic control of immune cell development by integrated carbon dioxide and hypoxia chemosensation in Drosophila.

Author information

1
Department of Life Science, College of Natural Science, Hanyang University, Seoul, 04763, Republic of Korea.
2
Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, 90095, USA.
3
Department of Molecular, Cell and Developmental Biology, University of California Los Angeles, Los Angeles, CA, 90095, USA. banerjee@mbi.ucla.edu.
4
Molecular Biology Institute, University of California Los Angeles, Los Angeles, CA, 90095, USA. banerjee@mbi.ucla.edu.
5
Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research, University of California Los Angeles, Los Angeles, CA, 90095, USA. banerjee@mbi.ucla.edu.
6
Department of Life Science, College of Natural Science, Hanyang University, Seoul, 04763, Republic of Korea. jshim@hanyang.ac.kr.
7
Research Institute for Natural Science, Hanyang University, Seoul, 04763, Republic of Korea. jshim@hanyang.ac.kr.
8
Research Institute for Convergence of Basic Sciences, Hanyang University, Seoul, 04763, Republic of Korea. jshim@hanyang.ac.kr.

Abstract

Drosophila hemocytes are akin to mammalian myeloid blood cells that function in stress and innate immune-related responses. A multi-potent progenitor population responds to local signals and to systemic stress by expanding the number of functional blood cells. Here we show mechanisms that demonstrate an integration of environmental carbon dioxide (CO2) and oxygen (O2) inputs that initiate a cascade of signaling events, involving multiple organs, as a stress response when the levels of these two important respiratory gases fall below a threshold. The CO2 and hypoxia-sensing neurons interact at the synaptic level in the brain sending a systemic signal via the fat body to modulate differentiation of a specific class of immune cells. Our findings establish a link between environmental gas sensation and myeloid cell development in Drosophila. A similar relationship exists in humans, but the underlying mechanisms remain to be established.

PMID:
29992947
PMCID:
PMC6041325
DOI:
10.1038/s41467-018-04990-3
[Indexed for MEDLINE]
Free PMC Article

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