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Database (Oxford). 2018 Jan 1;2018. doi: 10.1093/database/bay068.

Atlas of Schistosoma mansoni long non-coding RNAs and their expression correlation to protein-coding genes.

Author information

1
Laboratório de Expressão Gênica em Eucariotos, Instituto Butantan, 05503-900 São Paulo, SP, Brazil.
2
Departamento de Bioquímica, Instituto de Química, Universidade de São Paulo, 05508-900 São Paulo, SP, Brazil.
3
College of Veterinary Medicine, Western University of Health Sciences, Pomona, CA 91766-1854, USA.

Abstract

Long non-coding RNAs (lncRNAs) have been widely discovered in several organisms with the help of high-throughput RNA sequencing. LncRNAs are over 200 nt-long transcripts that do not have protein-coding (PC) potential, having been reported in model organisms to act mainly on the overall control of PC gene expression. Little is known about the functionality of lncRNAs in evolutionarily ancient non-model metazoan organisms, like Schistosoma mansoni, the parasite that causes schistosomiasis, one of the most prevalent infectious-parasitic diseases worldwide. In a recent transcriptomics effort, we identified thousands of S. mansoni lncRNAs predicted to be functional along the course of parasite development. Here, we present an online catalog of each of the S. mansoni lncRNAs whose expression is correlated to PC genes along the parasite life-cycle, which can be conveniently browsed and downloaded through a new web resource http://verjolab.usp.br. We also provide access now to navigation on the co-expression networks disclosed in our previous publication, where we correlated mRNAs and lncRNAs transcriptional patterns across five life-cycle stages/forms, pinpointing biological processes where lncRNAs might act upon.Database URL: http://verjolab.usp.br.

PMID:
29992321
PMCID:
PMC6041749
DOI:
10.1093/database/bay068
[Indexed for MEDLINE]
Free PMC Article

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