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Biomed Pharmacother. 2018 Oct;106:411-418. doi: 10.1016/j.biopha.2018.06.142. Epub 2018 Jul 11.

Cell type-dependent effects of ellagic acid on cellular metabolism.

Author information

1
Department of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, 6431 Fannin Street, Houston, TX, 77030, United States.
2
Department of Neurobiology and Anatomy, McGovern Medical School at UTHealth, 6431 Fannin Street, Houston, TX, 77030, United States.
3
Department of Biochemistry and Molecular Biology, McGovern Medical School at UTHealth, 6431 Fannin Street, Houston, TX, 77030, United States. Electronic address: Darren.F.Boehning@uth.tmc.edu.

Abstract

Ellagic acid is a botanical polyphenol which has been shown to have numerous effects on cellular function. Ellagic acid can induce apoptosis and inhibit the proliferation of various cancer cell types in vitro and in vivo. As such, ellagic acid has attracted significant interest as a potential chemotherapeutic compound. One mechanism by which ellagic acid has been proposed to affect cellular physiology is by regulating metabolic pathways. Here we show the dose-dependent effects of ellagic acid on cellular energy production and downstream induction of the apoptotic program in HEK293, HeLa, MCF7, and HepG2 cells. At physiologically relevant doses, ellagic acid has pleiotropic and cell-type specific effects on mitochondrial function. At high doses ellagic acid can also influence glycolytic pathways and induce cell death. Our results demonstrate that ellagic acid can influence mitochondrial function at therapeutically relevant concentrations. The observed effects of ellagic acid on cellular respiration are complex and cell type-specific, which may limit the chemotherapeutic utility of this compound.

KEYWORDS:

Apoptosis; Cancer; Ellagic acid; Glycolysis; Mitochondria; Respiration

PMID:
29990828
PMCID:
PMC6115283
[Available on 2019-10-01]
DOI:
10.1016/j.biopha.2018.06.142
[Indexed for MEDLINE]

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