Format

Send to

Choose Destination
J Ginseng Res. 2018 Jul;42(3):298-303. doi: 10.1016/j.jgr.2017.03.010. Epub 2017 Apr 4.

Ginsenoside Rg1 modulates medial prefrontal cortical firing and suppresses the hippocampo-medial prefrontal cortical long-term potentiation.

Author information

1
Department of Pharmacology, Yong Loo Lin School of Medicine, National University Health System, Singapore.
2
Neurobiology and Ageing Programme, Life Sciences Institute, National University of Singapore, Singapore.
3
Singapore Institute for Neurotechnology (SINAPSE), Singapore.
4
Department of Pharmacy, Faculty of Science, National University of Singapore, Singapore.
5
Department of Psychological Medicine, Yong Loo Lin School of Medicine, National University of Singapore, Singapore.

Abstract

Background:

Panax ginseng is one of the most commonly used medicinal herbs worldwide for a variety of therapeutic properties including neurocognitive effects. Ginsenoside Rg1 is one of the most abundant active chemical constituents of this herb with known neuroprotective, anxiolytic, and cognition improving effects.

Methods:

We investigated the effects of Rg1 on the medial prefrontal cortex (mPFC), a key brain region involved in cognition, information processing, working memory, and decision making. In this study, the effects of systemic administration of Rg1 (1 mg/kg, 3 mg/kg, or 10 mg/kg) on (1) spontaneous firing of the medial prefrontal cortical neurons and (2) long-term potentiation (LTP) in the hippocampal-medial prefrontal cortical (HP-mPFC) pathway were investigated in male Sprague-Dawley rats.

Results:

The spontaneous neuronal activity of approximately 50% the recorded pyramidal cells in the mPFC was suppressed by Rg1. In addition, Rg1 attenuated LTP in the HP-mPFC pathway. These effects were not dose-dependent.

Conclusion:

This report suggests that acute treatment of Rg1 impairs LTP in the HP-mPFC pathway, perhaps by suppressing the firing of a subset of mPFC neurons that may contribute to the neurocognitive effects of Rg1.

KEYWORDS:

ginsenoside Rg1; hippocampus; long-term potentiation; medical prefrontal cortex; single unit

Supplemental Content

Full text links

Icon for Elsevier Science Icon for PubMed Central
Loading ...
Support Center