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Nat Med. 2018 Sep;24(9):1324-1329. doi: 10.1038/s41591-018-0103-x. Epub 2018 Jul 9.

Biochemical autoregulatory gene therapy for focal epilepsy.

Author information

1
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, London, UK. a.lieb@ucl.ac.uk.
2
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, London, UK.
3
Department of Clinical and Experimental Epilepsy, UCL Institute of Neurology, University College London, London, UK. d.kullmann@ucl.ac.uk.

Abstract

Despite the introduction of more than one dozen new antiepileptic drugs in the past 20 years, approximately one-third of people who develop epilepsy continue to have seizures on mono- or polytherapy1. Viral-vector-mediated gene transfer offers the opportunity to design a rational treatment that builds on mechanistic understanding of seizure generation and that can be targeted to specific neuronal populations in epileptogenic foci2. Several such strategies have shown encouraging results in different animal models, although clinical translation is limited by possible effects on circuits underlying cognitive, mnemonic, sensory or motor function. Here, we describe an autoregulatory antiepileptic gene therapy, which relies on neuronal inhibition in response to elevations in extracellular glutamate. It is effective in a rodent model of focal epilepsy and is well tolerated, thus lowering the barrier to clinical translation.

PMID:
29988123
PMCID:
PMC6152911
DOI:
10.1038/s41591-018-0103-x
[Indexed for MEDLINE]
Free PMC Article

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