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Circ Genom Precis Med. 2018 Jul;11(7):e001926. doi: 10.1161/CIRCGEN.118.001926.

Clonal Hematopoiesis: Somatic Mutations in Blood Cells and Atherosclerosis.

Author information

1
Center for Genomic Medicine and Cardiovascular Research Center, Massachusetts General Hospital, Boston (P.N., S.K.). pnatarajan@mgh.harvard.edu.
2
Program in Medical and Population Genetics and Cardiovascular Disease Initiative, Broad Institute of Harvard and MIT, Cambridge, MA (P.N., S.K.).
3
Department of Medicine, Harvard Medical School, Boston, MA (P.N., S.K.).
4
Center for Genomic Medicine and Cardiovascular Research Center, Massachusetts General Hospital, Boston (P.N., S.K.).
5
Department of Pathology, Stanford University, CA (S.J.).

Abstract

The most important prognostic factor for atherosclerotic cardiovascular disease is age, independent of all other recognized risk factors. Recently, exome sequence analyses showed that somatic mutations in blood cells, a process termed clonal hematopoiesis, are common and increase in prevalence with age, with at least 1 in 10 adults older than 70 years affected. Carriers of clonal hematopoiesis have been shown to be not only at heightened risk for hematologic malignancy but also at increased risk for atherosclerotic cardiovascular disease. Here, we review the prior literature of clonal selection and expansion of hematopoietic stem cells and the evidence supporting its causal association with atherosclerotic cardiovascular disease.

KEYWORDS:

blood cell; clonal evolution; coronary artery disease; genetics; hematologic neoplasms; hematopoiesis; human

PMID:
29987111
PMCID:
PMC6082163
[Available on 2019-07-01]
DOI:
10.1161/CIRCGEN.118.001926

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