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J Clin Invest. 2018 Aug 1;128(8):3402-3412. doi: 10.1172/JCI97192. Epub 2018 Jul 9.

The cardiac lymphatic system stimulates resolution of inflammation following myocardial infarction.

Author information

1
Burdon-Sanderson Cardiac Science Centre, Department of Physiology, Anatomy and Genetics.
2
MRC Human Immunology Unit, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital.
3
Sir William Dunn School of Pathology, University of Oxford, Oxford, United Kingdom.

Abstract

Myocardial infarction (MI) arising from obstruction of the coronary circulation engenders massive cardiomyocyte loss and replacement by non-contractile scar tissue, leading to pathological remodeling, dysfunction, and ultimately heart failure. This is presently a global health problem for which there is no effective cure. Following MI, the innate immune system directs the phagocytosis of dead cell debris in an effort to stimulate cell repopulation and tissue renewal. In the mammalian adult heart, however, the persistent influx of immune cells, coupled with the lack of an inherent regenerative capacity, results in cardiac fibrosis. Here, we reveal that stimulation of cardiac lymphangiogenesis with VEGF-C improves clearance of the acute inflammatory response after MI by trafficking immune cells to draining mediastinal lymph nodes (MLNs) in a process dependent on lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1). Deletion of Lyve1 in mice, preventing docking and transit of leukocytes through the lymphatic endothelium, results in exacerbation of chronic inflammation and long-term deterioration of cardiac function. Our findings support targeting of the lymphatic/immune cell axis as a therapeutic paradigm to promote immune modulation and heart repair.

KEYWORDS:

Cardiovascular disease; Inflammation; Vascular Biology

PMID:
29985167
PMCID:
PMC6063482
DOI:
10.1172/JCI97192
[Indexed for MEDLINE]
Free PMC Article

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