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Neuroimage Clin. 2018 May 14;19:551-558. doi: 10.1016/j.nicl.2018.05.014. eCollection 2018.

The relationship between brain atrophy and cognitive-behavioural symptoms in retired Canadian football players with multiple concussions.

Author information

1
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Ave, Toronto, ON M5T 0S8, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
2
McConnell Brain Imaging Centre, Montreal Neurological Institute, 3801 Rue Universite, Montreal, QC H3A 2B4, Canada.
3
Canadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Neurology, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada.
4
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Ave, Toronto, ON M5T 0S8, Canada; Canadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada.
5
Canadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Brain, Imaging and Behaviour-Systems Neuroscience, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada.
6
Canadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Neurology, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Department of Surgery, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada; Division of Neurosurgery, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
7
Canadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Toronto Rehabilitation Institute, University Health Network, 550 University Ave., Toronto, ON M5G 2A2, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
8
Canadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Toronto Rehabilitation Institute, University Health Network, 550 University Ave., Toronto, ON M5G 2A2, Canada.
9
Canadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Brain, Imaging and Behaviour-Systems Neuroscience, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
10
Canadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Department of Medical Imaging, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada.
11
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Ave, Toronto, ON M5T 0S8, Canada.
12
Tanz Centre for Research in Neurodegenerative Diseases, University of Toronto, Krembil Discovery Tower, 60 Leonard Ave, Toronto, ON M5T 0S8, Canada; Canadian Concussion Center, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Division of Neurology, Krembil Neuroscience Centre, Toronto Western Hospital, 399 Bathurst St., Toronto, ON M5T 2S8, Canada; Institute of Medical Science, University of Toronto, 1 King's College Circle, Toronto, ON M5S 1A8, Canada. Electronic address: carmela.tartaglia@uhn.ca.

Abstract

Multiple concussions, particularly in contact sports, have been associated with cognitive deficits, psychiatric impairment and neurodegenerative diseases like chronic traumatic encephalopathy. We used volumetric and deformation-based morphometric analyses to test the hypothesis that repeated concussions may be associated with smaller regional brain volumes, poorer cognitive performance and behavioural symptoms among former professional football players compared to healthy controls. This study included fifty-three retired Canadian Football League players, 25 age- and education-matched healthy controls, and controls from the Cambridge Centre for Aging and Neuroscience database for validation. Volumetric analyses revealed greater hippocampal atrophy than expected for age in former athletes with multiple concussions than controls and smaller left hippocampal volume was associated with poorer verbal memory performance in the former athletes. Deformation-based morphometry confirmed smaller bilateral hippocampal volume that was associated with poorer verbal memory performance in athletes. Repeated concussions may lead to greater regional atrophy than expected for age.

KEYWORDS:

Aging; Deformation based morphometry; Mild traumatic brain injury; Sport-related concussion

PMID:
29984163
PMCID:
PMC6029563
DOI:
10.1016/j.nicl.2018.05.014
[Indexed for MEDLINE]
Free PMC Article

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