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Rev Alerg Mex. 2018 Apr-Jun;65(2):117-127. doi: 10.29262/ram.v65i2.301.

[Prevalence, incidence and factors associated with adverse reactions to foods in Cuban infants. A population-based cohort study].

[Article in Spanish; Abstract available in Spanish from the publisher]

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Instituto Nacional de Higiene, Epidemiología y Microbiología, La Habana, Cuba.


in English, Spanish


The prevalence of asthma and allergic diseases in Cuban children is high, but little is known about adverse reactions to foods.


To determine the prevalence, incidence and risk factors for adverse reaction to foods in children.


Population-based cohort study carried out in Havana, Cuba, in a three-year period. Parents of 1543 children provided medical and lifestyle information from the first to the third year of age, which was collected using a questionnaire. An adverse reaction to foods was defined by medical diagnosis reported by the parents or caregivers.


Annual cumulative incidence was 5.7%, 1.9% and 0.8%, whereas annual prevalence was 5.7%, 4% and 2.5% at 1, 2 and 3 years of age, respectively; 8% of infants had experienced an adverse reaction to foods when they turned 3 years of age. Cow milk was the most commonly implicated food. Main risk factors were allergenic food consumption, use of antibiotics, factors related to the presence of allergens, maternal history of overweight during pregnancy and allergy to insect bites.


Adverse reaction to food is a significant clinical problem in children from Havana. Modifiable risk factors were identified, the understanding of which will help to direct effective intervention strategies.


Adverse reactions to foods; Food allergy; Food intolerance

[Indexed for MEDLINE]

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