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J Infect Dis. 2018 Oct 20;218(11):1767-1772. doi: 10.1093/infdis/jiy397.

Chronic Kidney Disease Risk in African and Caribbean Populations With HIV.

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Institute for Global Health, University College London.
Department of Sexual Health, King's College Hospital NHS Foundation Trust, London.
Department of Sexual Health, Chelsea and Westminster Hospital NHS Foundation Trust, London.
Department of Sexual Health, Brighton and Sussex University Hospitals NHS Trust.
Division of Infectious Diseases, Department of Medicine, Imperial College London, United Kingdom.


We conducted an observational cohort study of end-stage kidney disease (ESKD) in >7000 African and Caribbean people with HIV in the UK. Using Poisson regression and East Africans as the reference group, the adjusted incidence rate ratio (95% confidence interval) of ESKD was 3.14 (1.26-7.84) in Southern Africans, 6.35 (2.53-15.96) in West Africans, and 5.26 (1.91-14.43) in Caribbeans. Higher CD4 cell count and suppressed HIV replication were associated with reduced risk of ESKD. The risk of ESKD varied among HIV-positive people of African heritage, with the highest rates observed in those of West African descent.

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