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J Infect Dis. 2018 Oct 20;218(11):1767-1772. doi: 10.1093/infdis/jiy397.

Chronic Kidney Disease Risk in African and Caribbean Populations With HIV.

Author information

1
Institute for Global Health, University College London.
2
Department of Sexual Health, King's College Hospital NHS Foundation Trust, London.
3
Department of Sexual Health, Chelsea and Westminster Hospital NHS Foundation Trust, London.
4
Department of Sexual Health, Brighton and Sussex University Hospitals NHS Trust.
5
Division of Infectious Diseases, Department of Medicine, Imperial College London, United Kingdom.

Abstract

We conducted an observational cohort study of end-stage kidney disease (ESKD) in >7000 African and Caribbean people with HIV in the UK. Using Poisson regression and East Africans as the reference group, the adjusted incidence rate ratio (95% confidence interval) of ESKD was 3.14 (1.26-7.84) in Southern Africans, 6.35 (2.53-15.96) in West Africans, and 5.26 (1.91-14.43) in Caribbeans. Higher CD4 cell count and suppressed HIV replication were associated with reduced risk of ESKD. The risk of ESKD varied among HIV-positive people of African heritage, with the highest rates observed in those of West African descent.

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