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Am J Clin Pathol. 2018 Aug 30;150(4):333-337. doi: 10.1093/ajcp/aqy051.

Prospective Postimplementation Study of Solana Group A Streptococcal Nucleic Acid Amplification Test vs Conventional Throat Culture.

Author information

1
Infectious Diseases Diagnostic Laboratory, University of Minnesota Medical Center and Fairview Health System, Minneapolis.
2
University of Minnesota Medical School, Minneapolis.

Abstract

Objectives:

We evaluated the Solana Group A Streptococcus Assay (Quidel, San Diego, CA), a nucleic acid amplification test (NAAT), as a substitute for backup culture on throat specimens with a negative rapid group A Streptococcus (GAS) antigen assay.

Methods:

During October 2016, all throat swabs from patients with a negative GAS antigen assay from local urgent care centers were processed by NAAT and conventional culture in real time.

Results:

The overall agreement of the 2,090 tested throat swab specimens of the NAAT with the culture was 2,050 (98%) of 2,090. Sensitivity, specificity, positive predictive value, and negative predictive value were 91.4%, 98.5%, 78.0%, and 99.5%, respectively.

Conclusions:

In summary, this postimplementation study supported high sensitivity and specificity of the GAS NAAT as a backup test for negative rapid GAS antigen tests.

PMID:
29982326
DOI:
10.1093/ajcp/aqy051
[Indexed for MEDLINE]

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