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J Infect. 2018 Dec;77(6):553-560. doi: 10.1016/j.jinf.2018.06.015. Epub 2018 Jul 5.

Impact of influenza on outpatient visits and hospitalizations among pregnant women in Catalonia, Spain.

Author information

1
Department of Preventive Medicine and Epidemiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, 119-129 Passeig Vall d'Hebron, 08035 Barcelona, Spain. Electronic address: draluzmaria@gmail.com.
2
Clinical & Health Informatics Research Group, Department of Epidemiology, Biostatistics and Occupational Health, McGill University, 1140 Pine Avenue West, H3A1A3 Montreal, Canada.
3
Laboratory for Mother and Child Health, Department of Public Health, IRCCS- Istituto di Ricerche Farmacologiche "Mario Negri", Via La Masa 19, 20156 Milan, Italy.
4
Department of Preventive Medicine and Epidemiology, Hospital Universitari Vall d'Hebron, Universitat Autònoma de Barcelona, 119-129 Passeig Vall d'Hebron, 08035 Barcelona, Spain.

Abstract

OBJECTIVE:

To estimate outpatient visits and hospitalization rates due to cardiopulmonary illness attributable to influenza from 2008-09 to 2012-13 in a large cohort of pregnant women from Catalonia, Spain.

METHODS:

We estimated the event rates occurring during influenza epidemic, influenza non-epidemic and non-influenza seasons, and by pregnancy status (one year before pregnancy, first, second and third trimester). We fitted quasi-Poisson models in order to identify the variables associated to higher event rates.

RESULTS:

During influenza epidemic seasons, pregnant women in their second trimester had the highest rates of outpatient visits (153 per 10,000 women-months). An increased risk of outpatient visits was associated to first or second trimester (adjusted rate ratio (aRR) = 1.17; 95% CI, 1.10-1.23 and aRR, 1.36; 95% CI, 1.28-1.43, respectively) and having any comorbidity (aRR = 1.28; 95% CI, 1.21-1.36). Women during third trimester had the highest rates of hospitalizations (1.60 per 10,000 women-months), and an increased risk of hospitalization was significantly associated to third trimester (aRR, 1.85; 95% CI, 1.01-3.39), having any comorbidity (aRR, 1.93; 95% CI, 1.10-3.41) and the pandemic influenza season (aRR, 2.90 (1.81; 95% CI, 1.81-4.64).

CONCLUSION:

Our findings provide significant information regarding influenza burden of disease among pregnant women.

KEYWORDS:

Comorbidity; Hospitalization; Influenza; Outpatient visit; Pregnancy; Pregnancy trimesters

PMID:
29981774
DOI:
10.1016/j.jinf.2018.06.015

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