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Biol Trace Elem Res. 2019 Feb;187(2):464-471. doi: 10.1007/s12011-018-1398-7. Epub 2018 Jul 6.

The Resveratrol Alleviates the Hepatic Toxicity of CuSO4 in the Rat.

Tian Y1, Wu B2,3, Li X4, Jin X5, Zhang F6, Jiang C7, Xu W8, Li H9, Wang H10,11.

Author information

1
Department of Dermatology and Venerology of the First Hospital, Jilin University, Changchun, 130021, China.
2
Department of Neurosurgery of China-Japan Union Hospital, Jilin University, Changchun, 130033, China.
3
Key Laboratory of Radiobiology (Ministry of Health) of Public Health, Jilin University, Changchun, 130033, China.
4
Department of Pediatric Endocrinology of the First Hospital, Jilin University, Changchun, 130021, China.
5
Department of Urology of China-Japan Union Hospital, Jilin University, Changchun, 130033, China.
6
Science and Research Center of China-Japan Union Hospital, Jilin University, Changchun, 130033, China.
7
Key Laboratory of Hormones and Development (Ministry of Health), Tianjin Key Laboratory of Metabolic Diseases, Tianjin Metabolic Diseases Hospital & Tianjin Institute of Endocrinology, Tianjin Medical University, Tianjin, 300070, China.
8
Department of Stomatology, Stomatological Hospital, Jilin University, Changchun, 130021, China.
9
Department of Hepatobiliary and pancreatic surgery, China-Japan Union Hospital, Jilin University, Changchun, 130033, China.
10
Department of Endocrinology and Metabolism of the First Hospital, Jilin University, Changchun, 130021, China. wanghywhy@126.com.
11
Department of Immunology in College of Basic Medical Sciences, Jilin University, Changchun, 130021, China. wanghywhy@126.com.

Abstract

Cu is toxic to humans and other animals. Oxidative stress is an important mechanism involved in Cu toxicity. Resveratrol (RSV) is an antioxidative compound, so could counteract Cu toxicity. The aim of this study was to determine whether RSV protects the liver from the effects of CuSO4. Forty male Sprague-Dawley rats (5 weeks old, 110-120 g) were divided into four groups (n = 10 per group), a control group and groups treated with CuSO4 at a dose of 200 mg/kg body weight (BW), RSV at a dose of 15 mg/kg BW, and CuSO4 at a dose of 200 mg/kg BW and RSV at a dose of 15 mg/kg BW. The treatments were orally administered for 30 days. The livers were removed from the rats at the end of the study, and the cytochrome P450, cytochrome b5, Cu, Fe, Zn, glutathione peroxidase, superoxide dismutase, reactive oxygen species, aspartate aminotransferase, and alanine aminotransferase concentrations in the livers were determined. CuSO4 decreased the BW, liver weight, and cytochrome P450, cytochrome b5, Fe, Zn, glutathione peroxidase, and superoxide dismutase concentrations but increased the Cu, aspartate aminotransferase, alanine aminotransferase, and reactive oxygen species concentrations relative to the control group. RSV alleviated the toxic effects of CuSO4 on the liver, indicating that RSV attenuates CuSO4-induced liver injury by decreasing the liver transaminase concentration and oxidative stress, promoting antioxidative activity and cytochrome P450 enzymes, and maintaining balance in the trace element concentrations. The results indicate that RSV could be used to treat CuSO4 toxicity.

KEYWORDS:

CuSO4 toxicity; Oxidative stress; Resveratrol; Trace element

PMID:
29980948
DOI:
10.1007/s12011-018-1398-7
[Indexed for MEDLINE]

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