Format

Send to

Choose Destination
Mol Nutr Food Res. 2018 Aug;62(16):e1800373. doi: 10.1002/mnfr.201800373. Epub 2018 Aug 1.

Functional Effects of the Buckwheat Iminosugar d-Fagomine on Rats with Diet-Induced Prediabetes.

Author information

1
Institute of Advanced Chemistry of Catalonia (IQAC-CSIC), Barcelona, 08034, Spain.
2
Department of Cell Biology, Physiology and Immunology, Faculty of Biology, University of Barcelona, Barcelona, 08028, Spain.
3
Department of Pathology, Puerta del Mar University Hospital, Cádiz, 11009, Spain.
4
Research Unit on Bioactive Molecules (RUBAM), Department of Biomedicinal Chemistry, Institute of Advanced Chemistry of Catalonia (IQAC-CSIC) and CIBEREHD, Barcelona, 08034, Spain.
5
Facultat de Medicina i Ciències de la Salut, Universitat Rovira i Virgili, Reus, 43201, Spain.
6
Departament d'Enginyeria Química i Química Analítica and Institut de Biomedicina, Universitat de Barcelona, Barcelona, 08028, Spain.
7
Instituto de Investigaciones Marinas (IIM-CSIC), Vigo, 36208, Spain.

Abstract

SCOPE:

The goals of this work are to test if d-fagomine, an iminosugar that reduces body weight gain, can delay the appearance of a fat-induced prediabetic state in a rat model and to explore possible mechanisms behind its functional action.

METHODS AND RESULTS:

Wistar Kyoto rats were fed a high-fat diet supplemented with d-fagomine (or not, for comparison) or a standard diet (controls) for 24 weeks. The variables measured were fasting blood glucose and insulin levels; glucose tolerance; diacylglycerols as intracellular mediators of insulin resistance in adipose tissue (AT), liver, and muscle; inflammation markers (plasma IL-6 and leptin, and liver and AT histology markers); eicosanoids from arachidonic acid as lipid mediators of inflammation; and the populations of Bacteroidetes, Firmicutes, Enterobacteriales, and Bifidobacteriales in feces. It was found that d-fagomine reduces fat-induced impaired glucose tolerance, inflammation markers, and mediators (hepatic microgranulomas and lobular inflammation, plasma IL-6, prostaglandin E2 , and leukotriene B4 ) while attenuating the changes in the populations of Enterobacteriales and Bifidobacteriales.

CONCLUSION:

d-Fagomine delays the development of a fat-induced prediabetic state in rats by reducing low-grade inflammation. We suggest that the anti-inflammatory effect of d-fagomine may be linked to a reduction in fat-induced overpopulation of minor gut bacteria.

KEYWORDS:

diabetes; iminocyclitol; iminosugars; inflammation; microbiota; obesity

PMID:
29979820
DOI:
10.1002/mnfr.201800373

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center