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Arch Pharm Res. 2018 Jul;41(7):743-752. doi: 10.1007/s12272-018-1052-0. Epub 2018 Jul 6.

Lifespan-extending property of 6-shogaol from Zingiber officinale Roscoe in Caenorhabditis elegans.

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College of Pharmacy, Woosuk University, Jeonju, 55338, Republic of Korea.
Department of Agro-food Resources, Rural Development Administration, Wanju, 55365, Republic of Korea.
College of Pharmacy, Woosuk University, Jeonju, 55338, Republic of Korea.


Aging is a key risk factor for many diseases, understanding the mechanism of which is becoming more important for drug development given the fast-growing aging population. In the course of our continued efforts to discover anti-aging natural products, the active constituent 6-shogaol was isolated from Zingiber officinale Roscoe. The chemical structure of 6-shogaol was identified by comparison of its NMR data with literature values. The lifespan-extending effect of 6-shogaol was observed in a dose-dependent manner in Caenorhabditis elegans that has been widely used as a model organism for human aging studies. Mechanism of such action was investigated using C. elegans models, suggesting that 6-shogaol is capable of increasing stress tolerances via enzyme induction. The proposed mechanism was further supported by observation of the increase in SOD and HSP expressions upon treatment with 6-shogaol in transgenic strains of C. elegans which contain GFP-based reporters. In addition, the mechanism was elaborated by confirming that the effect observed for 6-shogaol is independent from other aging-related factors that are known to affect the aging process of C. elegans.


6-Shogaol; Aging; Anti-aging natural products; Caenorhabditis elegans; Lifespan-extending effect; Zingiber officinale Roscoe

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