Format

Send to

Choose Destination
Int J Ophthalmol. 2018 Jun 18;11(6):970-975. doi: 10.18240/ijo.2018.06.12. eCollection 2018.

Macular pigment and serum zeaxanthin levels with Goji berry supplement in early age-related macular degeneration.

Author information

1
Department of Ophthalmology, Beijing YouAn Hospital, Capital Medical University Beijing, Beijing100069, China.
2
Department of Ophthalmology, China Rehabilitation Research Center, Chinese Rehabilitation Science Institute, Capital Medical University, Beijing 100068, China.
3
Research Center, Xiyuan Hospital, China Academy of Chinese Medical Science, Beijing 100091, China.

Abstract

AIM:

To evaluate the efficacy of Goji berry supplementation on improving macular pigment, serum zeaxanthin levels and visual acuity in patients with early age-related macular degeneration (AMD).

METHODS:

A total of 114 patients (aged from 51 to 92y, mean age 69.53±8.41y) with early AMD were enrolled in our prospective, randomized controlled study. The included patients were assigned randomly to the Goji group (n=57) with 25 g of Goji berries supplementation per day for 90d and the control group (n=57) with their normal diet for 90d. Macular pigment optical density (MPOD) was measured using heterochromatic flicker photometry (HFP). The levels of serum lutein (L)/zeaxanthin (Z) were analyzed using high-performance liquid chromatography (HPLC). MPOD, serum L/Z levels and best corrected visual acuity (BCVA) were recorded at baseline and 90d.

RESULTS:

In the Goji group, there were no statistically significant differences in the serum L levels between the baseline (0.199±0.149 µmol/mL) and 90d (0.203±0.181 µmol/mL) (t=-0.186, P=0.850); however the serum Z levels were increased at 90d (0.101±0.087 µmol/mL) compared with those at the baseline (0.029±0.032 µmol/mL) (t=6.412, P<0.001). Patients treated with Goji berry for 90d showed an elevated MPOD (0.877±0.202 DU) from the baseline (0.731±0.205 DU) (t=-4.741, P=0.000). In contrast to the control group, the serum Z levels and MPOD were higher in the Goji group at 90d (both P<0.05). At 90d, patients with Goji berry supplementation had a relative decrease in BCVA (0.21±0.18 logMAR) compared with the baseline (0.27±0.20) (t=2.397, P=0.020).

CONCLUSION:

Overall, daily supplementation with Goji berry for 90d improves MPOD by increasing serum Z levels rather than serum L levels in early AMD patients. Goji berry may be an effective therapeutic intervention for preventing the progression of early AMD.

KEYWORDS:

Goji berry; early age-related macular degeneration; zeaxanthin

Supplemental Content

Full text links

Icon for PubMed Central
Loading ...
Support Center