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Gut Pathog. 2018 Jun 22;10:25. doi: 10.1186/s13099-018-0253-x. eCollection 2018.

Tigecycline application in a 3-month-old infant with multiple drug resistant Klebsiella pneumonia: a case report.

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Department of Neonatal Ward, Peking University First Hospital, No. 1, Xi Anmen Street, Xicheng District, Beijing, 100034 China.



Tigecycline is an 'immature' antibiotic for children. We report the youngest surviving patient who received a complete tigecycline treatment, and no significant adverse effects occurred in the patient.

Case presentation:

The 3-month old infant suffered from a catheter-associated bloodstream infection by multiple drug resistant Klebsiella pneumoniae. Tigecycline was considered as a salvage therapy to control the severe sepsis. The therapy consisted of 3 mg/kg as a loading dose and 1.5 mg/kg Q12 h as a maintenance dose for 26 days.


Current researches are limited in clinical trials directly focused on children. This therapeutic schedule might be safe for patients who are above 3 months old.


Klebsiella pneumoniae; Multiple drug resistant; Pediatric; Tigecycline

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