Format

Send to

Choose Destination
J Cell Biol. 2018 Aug 6;217(8):2613-2614. doi: 10.1083/jcb.201806018. Epub 2018 Jul 5.

Directed migration: Cells navigate by extracellular vesicles.

Author information

1
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN.
2
Department of Cell and Developmental Biology, Vanderbilt University School of Medicine, Nashville, TN alissa.weaver@vanderbilt.edu.
3
Department of Pathology, Microbiology, and Immunology, Vanderbilt University Medical Center, Nashville, TN.

Abstract

Directional cell motility toward a chemical gradient, chemotaxis, is critical during inflammation, embryogenesis, and cancer metastasis. In this issue, Kriebel et al. (2018. J. Cell Biol. https://doi.org/10.1083/jcb.201710170) demonstrate that the key cAMP chemoattractant for Dictyostelium discoideum amoebas is synthesized within and released from extracellular vesicles to promote chemotaxis.

PMID:
29976599
PMCID:
PMC6080936
DOI:
10.1083/jcb.201806018
[Indexed for MEDLINE]
Free PMC Article

Supplemental Content

Full text links

Icon for HighWire Icon for PubMed Central
Loading ...
Support Center