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J Food Drug Anal. 2018 Jul;26(3):1015-1023. doi: 10.1016/j.jfda.2017.12.006. Epub 2018 Feb 2.

Synergic effect of curcumin and its structural analogue (Monoacetylcurcumin) on anti-influenza virus infection.

Author information

1
Department of Biology and Chemistry, Azusa Pacific University, Azusa, CA, USA.
2
Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung, Taiwan.
3
Graduate School of Agriculture, Shinshu University, Kamiina-gun, Nagano, 399-4598, Japan.
4
Department of Microbiology and Immunology, Chung Shan Medical University, Taichung, 402, Taiwan.
5
Graduate Institute of Biotechnology, National Chung-Hsing University, Taichung, Taiwan.
6
Institute of Biotechnology and Pharmaceutical Research, National Health Research Institute, Miaoli County, 35053, Taiwan.
7
Graduate Institute of Microbiology and Public Health, National Chung Hsing University, Taichung, Taiwan. Electronic address: wlhsu@dragon.nchu.edu.tw.

Abstract

Curcumin (Cur), a polyphenolic compound extracted from spice and common food colourant turmeric, contains versatile bio-activities. Monoacetylcurcumin (MAC), a structural analogue of Cur, differs from Cur by acetyl modification, but retains enone groups. Comparative analysis revealed MAC effectively inhibited influenza virus infection (IAV) to a similar extent as, if not superior to, curcumin. Both compounds mildly reduced viral NA activity. Surprisingly, unlike Cur, the MAC inhibition of IAV did not occur through the blocking of HA activity. However, MAC strongly dampened Akt phosphorylation, the prerequisite signalling for efficient IAV propagation. A much stronger inhibition effect on IAV infection was observed when MAC treatment was in combination with Cur. Collectively, MAC demonstrated clear antiviral activity, and likely inhibited IAV via multiple mechanisms that were not identical to Cur. Importantly, Cur and MAC in combination synergistically inhibited IAV infection.

KEYWORDS:

Antiviral; Curcumin; Haemagglutinin; Influenza virus; Synergic

PMID:
29976394
DOI:
10.1016/j.jfda.2017.12.006
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