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Nature. 1985 Nov 7-13;318(6041):36-40.

An inherited limb deformity created by insertional mutagenesis in a transgenic mouse.

Abstract

We have created an insertional mutation that leads to a severe defect in the pattern of limb formation in the developing mouse. The novel recessive mutation is phenotypically identical and non-complementary to two previously encountered limb deformity mutations, and is closely linked to a dominant mutation that gives rise to a related limb dysmorphism. The inserted element thus provides a molecular genetic link with the control of pattern formation in the mammalian embryo.

PMID:
2997621
DOI:
10.1038/318036a0
[Indexed for MEDLINE]

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