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J Pediatr Endocrinol Metab. 2018 Aug 28;31(8):829-836. doi: 10.1515/jpem-2018-0141.

Urinary bisphenol-A levels in children with type 1 diabetes mellitus.

Author information

1
Dokuz Eylul University, Faculty of Medicine, Department of Pediatrics, Social Pediatrics Unit, İnciraltı Mahallesi Mithatpaşa, Street No: 56, Balçova, 35340 İzmir, Turkey.
2
Hacettepe University, Faculty of Pharmacy, Department of Toxicology, Sihhiye, Ankara, Turkey.
3
Hacettepe University, Faculty of Medicine, Department of Pediatrics, Sihhiye, Ankara, Turkey.
4
Erzincan University, Faculty of Pharmacy, Department of Toxicology, Erzincan, Turkey.
5
Lokman Hekim University, Faculty of Pharmacy, Department of Toxicology, Çankaya/Ankara, Turkey.

Abstract

BACKGROUND:

Bisphenol-A (BPA) is one of the most abundantly produced chemicals globally. Concerns have been raised about BPA's possible role in the pathogenesis of type 1 diabetes mellitus (T1DM). The main aim of the current study was to evaluate the possible association between BPA exposure and T1DM. The second aim was to investigate children's possible BPA exposure routes in Turkey.

METHODS:

A total of 100 children aged between 5 and 18 years including 50 children with T1DM and 50 healthy children were included. Urinary BPA levels of all children were measured using high-performance liquid chromatography. Mothers of children enrolled in the study were also requested to complete a survey that included questions on the sociodemographic characteristics, medical history and possible BPA exposure routes of their children.

RESULTS:

In the T1DM group, urinary BPA levels were slightly higher compared to the control group, but this difference was not significant (p=0.510). However, there was an inverse relationship between current urinary BPA levels and birth weight. It was found that the use of plastic kettles and the consumption of dairy products in plastic boxes significantly increased the urinary BPA concentrations in all subjects.

CONCLUSIONS:

Although there was no significant association between urinary BPA levels and T1DM, we found an inverse relationship between current urinary BPA levels and birth weight. This finding might be important for prenatal exposure, and further prospective research must be conducted. Also, the use of plastic kettles, which has not been mentioned much in the literature before, was found to be an important exposure route for BPA.

KEYWORDS:

bisphenol-A; children; endocrine disrupting chemicals; type 1 diabetes mellitus

PMID:
29975667
DOI:
10.1515/jpem-2018-0141
[Indexed for MEDLINE]

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