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Annu Rev Phytopathol. 2018 Aug 25;56:479-512. doi: 10.1146/annurev-phyto-080417-050158. Epub 2018 Jul 5.

CRISPR Crops: Plant Genome Editing Toward Disease Resistance.

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The Sainsbury Laboratory, Norwich Research Park, Norwich, NR4 7UH, United Kingdom; email:


Genome editing by sequence-specific nucleases (SSNs) has revolutionized biology by enabling targeted modifications of genomes. Although routine plant genome editing emerged only a few years ago, we are already witnessing the first applications to improve disease resistance. In particular, CRISPR-Cas9 has democratized the use of genome editing in plants thanks to the ease and robustness of this method. Here, we review the recent developments in plant genome editing and its application to enhancing disease resistance against plant pathogens. In the future, bioedited disease resistant crops will become a standard tool in plant breeding.


CRISPR-Cas9; TALENs; disease resistance; genome editing; sequence-specific nucleases; susceptibility genes

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