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Chemistry. 2018 Sep 25;24(54):14448-14460. doi: 10.1002/chem.201802577. Epub 2018 Sep 3.

On-Chip Screening of a Glycomimetic Library with C-Type Lectins Reveals Structural Features Responsible for Preferential Binding of Dectin-2 over DC-SIGN/R and Langerin.

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Dipartimento di Chimica, Università degli Studi di Milano, Via Golgi 19, 20133, Milano, Italy.
Univ. Grenoble Alpes, CEA, CNRS, Institut de Biologie Structurale, 38000, Grenoble, France.
Glycotechnology laboratory, CIC biomaGUNE, Paseo Miramón 182, 20014, Donostia-San Sebastián, Spain.
University of Dundee, Dundee, UK.
CIBER-BBN, 20014, Donostia-San Sebastián, Spain.


A library of mannose- and fucose-based glycomimetics was synthesized and screened in a microarray format against a set of C-type lectin receptors (CLRs) that included DC-SIGN, DC-SIGNR, langerin, and dectin-2. Glycomimetic ligands able to interact with dectin-2 were identified for the first time. Comparative analysis of binding profiles allowed their selectivity against other CLRs to be probed.


C-type lectins; carbohydrates; drug discovery; glycomimetics; microarrays

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