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Jpn J Ophthalmol. 2018 Sep;62(5):544-553. doi: 10.1007/s10384-018-0608-3. Epub 2018 Jul 4.

Additive effects of orthokeratology and atropine 0.01% ophthalmic solution in slowing axial elongation in children with myopia: first year results.

Author information

1
Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama, 330-8503, Japan. nozomik@omiya.jichi.ac.jp.
2
Konno Eye Clinic, Saitama, Japan.
3
Omiya Hamada Eye Clinic, Saitama, Japan.
4
Department of Hematology, Saitama Medical Center, Jichi Medical University, Saitama, Japan.
5
Department of Ophthalmology, Saitama Medical Center, Jichi Medical University, 1-847 Amanuma-cho, Omiya-ku, Saitama-shi, Saitama, 330-8503, Japan.

Abstract

PURPOSE:

To investigate the additive effects of orthokeratology (OK) and atropine 0.01% ophthalmic solution, both of which are effective procedures to slow axial elongation in children with myopia.

STUDY DESIGN:

Prospective randomized clinical trial.

METHODS:

Japanese children aged 8-12 years with a spherical equivalent refractive error of - 1.00 to - 6.00 diopters were included. A total of 41 participants who had been wearing the OK lenses successfully for 3 months were randomly allocated into two groups to receive either the combination of OK and atropine 0.01% ophthalmic solution (combination group) or monotherapy with OK (monotherapy group). Subjects in the combination group started to use atropine 0.01% ophthalmic solution once nightly from 3 months after the start of OK. Axial length was measured every 3 months using non-contact laser interferometry (IOLMaster), and the axial length measurement at month 3 of OK therapy was used as the baseline value in both groups. The increase in axial length over 1 year was compared between the two groups.

RESULTS:

A total of 40 consecutive subjects (20 subjects in the combination group and 20 in the monotherapy group) were followed for 1 year. The increase in axial length over 1 year was 0.09 ± 0.12 mm in the combination group and 0.19 ± 0.15 mm in the monotherapy group (P = 0.0356, unpaired t test).

CONCLUSION:

During the 1-year follow-up, the combination of OK and atropine 0.01% ophthalmic solution was more effective in slowing axial elongation than OK monotherapy in children with myopia.

KEYWORDS:

Additive effects; Atropine 0.01% ophthalmic solution; Axial length; Myopia; Orthokeratology

PMID:
29974278
DOI:
10.1007/s10384-018-0608-3
[Indexed for MEDLINE]

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