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Cell Metab. 2018 Jul 3;28(1):3-4. doi: 10.1016/j.cmet.2018.06.017.

A Glycolysis Outsider Steps into the Cancer Spotlight.

Author information

1
Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA; Division of Endocrinology, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA.
2
Meyer Cancer Center, Department of Medicine, Weill Cornell Medicine, New York, NY 10021, USA. Electronic address: lcantley@med.cornell.edu.

Abstract

Glycolysis is prudently regulated and coupled to cell growth. Phosphofructokinase 2 controls glycolytic flux by generating fructose 2,6-bisphosphate, an allosteric activator of phosphofructokinase 1. In a recent paper in Nature, Dasgupta et al. address the novel role of PFKFB4, an isoform of phosphofructokinase 2, in regulating gene expression to promote tumor growth.

PMID:
29972796
DOI:
10.1016/j.cmet.2018.06.017
[Indexed for MEDLINE]

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