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J Asthma. 2019 Jul;56(7):731-738. doi: 10.1080/02770903.2018.1490754. Epub 2018 Oct 16.

Depression symptoms and quality of life among individuals with aspirin-exacerbated respiratory disease.

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a Ferkauf Graduate School of Psychology , Yeshiva University , Bronx , NY , USA.
b Albert Einstein College of Medicine/Montefiore Medical Center , Bronx , NY , USA.
c Albert Einstein College of Medicine , Bronx , NY , USA.
d Washington University School of Medicine , St. Louis , MO , USA.



Patients with aspirin-exacerbated respiratory disease (AERD) have high disease burden due to the severity of asthma and sinonasal symptoms. There is limited research on the psychological well-being and subjective experiences of patients with AERD. This study examined levels of depression symptoms, asthma-related quality of life and asthma control among AERD patients.


Thirty-two adults with AERD and 39 patients without AERD (asthma-only) were recruited from outpatient asthma/allergy clinics. The sample was largely comprised of ethnic minority, inner-city patients who ranged in age from 19 to 84 years old. Participants completed the Beck Depression Inventory (BDI), the Mini Asthma Quality of Life Questionnaire (Mini AQLQ), a self-report rating of asthma severity and spirometry testing. Asthma control and severity were determined following national guidelines.


AERD patients reported lower levels of depression symptoms (p = 0.049), better overall asthma-related quality of life (p < 0.001), and perceived their asthma to be less severe (p = 0.01) compared to asthma-only patients. However, clinician ratings of asthma severity were more severe for AERD than asthma-only patients (p = 0.006). No significant differences were found between the groups on asthma controller medications or oral corticosteroid bursts for asthma.


AERD patients may be resilient given their low levels of depression symptoms and positive views of asthma-related impairment despite higher clinician-rated asthma severity. The adult onset nature of asthma in AERD might be a protective factor on mental health. Future studies should explore mechanisms linking AERD and positive psychological health outcomes and subjective perception of asthma.


Mental health; minority groups; protective factors; resilience; signs and symptoms

[Available on 2020-07-01]

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