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Cell Death Dis. 2018 Jul 3;9(7):752. doi: 10.1038/s41419-018-0715-6.

MiR-133b targets Sox9 to control pathogenesis and metastasis of breast cancer.

Author information

1
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM), 200025, Shanghai, China.
2
Institute of Health Sciences, Shanghai Jiao Tong University School of Medicine (SJTU-SM) & Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), 200025, Shanghai, China.
3
Department of General Surgery, Rui-Jin Hospital, Shanghai Jiao Tong University School of Medicine, 200025, Shanghai, China. HEJRONG@hotmail.com.
4
Department of Pathophysiology, Key Laboratory of Cell Differentiation and Apoptosis of National Ministry of Education, Shanghai Jiao Tong University School of Medicine (SJTU-SM), 200025, Shanghai, China. qzhao@shsmu.edu.cn.

Abstract

The miR-133b, a commonly recognized muscle-specific miRNA, was reported to be deregulated in many kinds of cancers. However, its potential roles in tumorigenesis remain greatly elusive. Herein, we demonstrate that miR-133b is significantly suppressed in human breast cancer specimens, which is reversely correlated to histological grade of the cancer. Ectopic expression of miR-133b suppresses clonogenic ability and metastasis-relevant traits in vitro, as well as carcinogenesis and pulmonary metastasis in vivo. Further studies have identified Sox9, c-MET, and WAVE2 as direct targets of miR-133b, in which Sox9 contributes to all miR-133b-endowed effects including cell proliferation, colony formation, as well as cell migration and invasion in vitro. Moreover, re-expression of Sox9 reverses miR-133b-mediated metastasis suppression in vivo. Taken together, these findings highlight an important role for miR-133b in the regulation of tumorigenesis and metastatic potential of breast cancer and suggest a potential application of miR-133b in cancer treatment.

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