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Biomacromolecules. 2018 Aug 13;19(8):3212-3223. doi: 10.1021/acs.biomac.8b00360. Epub 2018 Jul 18.

Reversible Fusion Proteins as a Tool to Enhance Uptake of Virus-Functionalized LbL Microcarriers.

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Institute for Medical Physics and Biophysics, Faculty of Medicine , University of Leipzig , Leipzig , Germany.
Institute of Virology, Faculty of Medicine , University of Leipzig , Leipzig , Germany.
Schaller research group at CellNetworks, Department of Infectious Diseases, Virology , Heidelberg University Hospital , Heidelberg , Germany.
Research Group "Cellular polarity and viral infection" (F140), German Cancer Research Center (DKFZ), Heidelberg , Germany.


For the efficient treatment of an increasing number of diseases the development of new therapeutics as well as novel drug delivery systems is essential. Such drug delivery systems (DDS) must not only consider biodegradability and protective packaging but must also target and control the release of active substances, which is one of the most important points in DDS application. We highlight the improvement of these key aspects, the increased interaction rate of Layer-by-Layer (LbL) designed microcarriers as a promising DDS after functionalization with vesicular stomatitis virus (VSV). We make use of the unique conformational reversibility of the fusion protein of VSV as a surface functionalization of LbL microcarriers. This reversibility allows for VSV to be used both as a tool for assembly onto the DDS and as an initiator for an efficient cellular uptake. We could show that the evolutionary optimized viral fusion machinery can be successfully combined with a biophysical DDS for optimization of its cellular interaction.

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