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ACS Appl Mater Interfaces. 2018 Jul 25;10(29):24450-24458. doi: 10.1021/acsami.8b08595. Epub 2018 Jul 11.

Gold Nanoparticles Bearing a Tumor pH-Sensitive Cyclodextrin Cap.

Author information

1
Department of Biotechnology , The Catholic University of Korea , 43 Jibong-ro , Bucheon-si , Gyeonggi-do 14662 , Republic of Korea.
2
College of Pharmacy , Chung-Ang University , 84 Heukseok-ro , Dongjak-gu, Seoul 06974 , Republic of Korea.

Abstract

We report functional gold nanoparticles (AuNPs) with a pH-sensitive γ-cyclodextrin (CD) cap. These particles include two chargeable CD molecules on their surface. CD with dopamine and amine (NH2) groups (hereafter termed as dCD-NH2) was anchored to the gold surface and then electrostatically complexed with the CD with 2,3-dimethylmaleic acid (DMA) and chlorin e6 (Ce6) (hereafter termed as cCD-DMA), producing an ionic complex consisting of dCD-NH2 and cCD-DMA. Under the acidic environment (pH 6.8) existing in most solid tumors, the ionic complex was destabilized because of the decoupling of DMA, resulting in the release of cCD (without DMA) from the AuNPs, resulting in extensive tumoral uptake of AuNPs with dCD-NH2 (because of their electrostatic attraction to tumor cells). This event resulted in a significant increase in the efficiency of cellular AuNP uptake and light-driven (AuNP-mediated photothermal and Ce6-mediated photodynamic) ablation of acidic solid tumors, suggesting marked potential for tumor therapy.

KEYWORDS:

gold nanoparticles; pH-sensitive cyclodextrin cap; photodynamic therapy; photothermal therapy; tumor acidic pH

PMID:
29963860
DOI:
10.1021/acsami.8b08595
[Indexed for MEDLINE]

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