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Bone Rep. 2018 Apr 18;8:163-167. doi: 10.1016/j.bonr.2018.04.004. eCollection 2018 Jun.

Vitamin D and muscle.

Gunton JE1,2,3,4, Girgis CM1,2,3,5.

Author information

1
Centre for Diabetes, Obesity and Endocrinology Research, The Westmead Institute of Medical Research, Westmead, Sydney, Australia.
2
The Faculty of Medicine, The University of Sydney, Australia.
3
Department of Diabetes and Endocrinology, Westmead Hospital, Sydney, Australia.
4
Division of Immunology, Garvan Institute of Medical Research, Sydney, Australia.
5
Department of Diabetes and Endocrinology, Royal North Shore Hospital, Sydney, Australia.

Abstract

Vitamin D is increasingly recognised to play an important role in normal muscle function. Low vitamin D status is associated with an increased risk of falls and proximal weakness. Since vitamin D deficiency is very common, and the signs are non-specific, it is important to maintain a high index of suspicion of vitamin D deficiency in patients with muscle pain and weakness, and it is simple to measure serum 25(OH) vitamin D. Therapy is cheap, safe and effective, but sometimes a larger dose may be needed, and, as shown in our case report, willingness of people to pay for an over the counter medication can be an issue. Following a striking case report that demonstrates muscle defects in severe vitamin D deficiency, we discuss clinical studies examining specific effects of vitamin D on physical performance, muscle strength and falls. Finally, we present an overview of molecular mechanisms that explain vitamin D's biological effects on muscle.

KEYWORDS:

Muscle; Myalgia; Myopathy; Sarcopenia; Vitamin D

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